The prevention of haemolytic disease of the newborn.
نویسنده
چکیده
Prior to the availability of anti-D immunoglobulin (anti-D Ig), the incidence of Rh(D) alloimmunisation in D negative women following two deliveries of D positive, ABO-compatible infants was approximately 16%, and haemolytic disease of the newborn (HDN) due to anti-D was a significant cause of morbidity and mortality. Following routine post-partum administration of anti-D Ig, the rate of alloimmunisation dropped to approximately 2%. A further reduction in the sensitisation rate ranging from 0·17 to 0·28% was achieved by introducing routine antenatal prophylaxis during the third trimester of pregnancy. Associated with this reduction in sensitisation is a reduction in mortality associated with HDN, from 46/100 000 births to 1·6/100 000 births.
منابع مشابه
BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn.
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ورودعنوان ژورنال:
- Irish journal of medical science
دوره 6 498 شماره
صفحات -
تاریخ انتشار 1967