The prevention of haemolytic disease of the newborn.

نویسنده

  • D E Mellon
چکیده

Prior to the availability of anti-D immunoglobulin (anti-D Ig), the incidence of Rh(D) alloimmunisation in D negative women following two deliveries of D positive, ABO-compatible infants was approximately 16%, and haemolytic disease of the newborn (HDN) due to anti-D was a significant cause of morbidity and mortality. Following routine post-partum administration of anti-D Ig, the rate of alloimmunisation dropped to approximately 2%. A further reduction in the sensitisation rate ranging from 0·17 to 0·28% was achieved by introducing routine antenatal prophylaxis during the third trimester of pregnancy. Associated with this reduction in sensitisation is a reduction in mortality associated with HDN, from 46/100 000 births to 1·6/100 000 births.

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عنوان ژورنال:
  • Irish journal of medical science

دوره 6 498  شماره 

صفحات  -

تاریخ انتشار 1967